Prof. Dr. Nathalie Grob
Prof. Dr. Nathalie Grob
SNSF Professor at the Department of Chemistry and Applied Biosciences
ETH Zürich
Peptid-basierte Wirkstoffentdeck.
Additional information
Research area
Nathalie Grob's research aims to develop efficient methods for the discovery of novel drug modalities. The research of her group focuses on the therapeutic modulation of protein–protein interactions by peptide-based modalities. Through the use of combinatorial chemistry and high-resolution mass spectrometry her group follows a multidisciplinary approach to develop robust workflows for hit identification.
Nathalie Grob's work centers on diseases and conditions that are relevant to the health of women and girls and have been rarely studied in the past.
Nathalie Grob earned her BSc in Pharmaceutical Sciences and MSc in Pharmacy from the University of Basel in Switzerland. For her MSc thesis, she joined the group of Prof. Ulf Göransson at Uppsala University in Sweden to study structure-activity relationships in complex peptide natural products. She subsequently pursued a PhD at ETH Zürich with Prof. Roger Schibli and Prof. Thomas Mindt, where she worked on the development of radiolabeled peptides for cancer diagnosis and treatment. From 2020–2023, Nathalie Grob was a postdoctoral researcher in the group of Prof. Bradley Pentelute at the Massachusetts Institute of Technology. Her postdoctoral research focused on early-stage drug discovery of small molecules and peptides. In April 2024 she returned to the Department of Chemistry and Applied Sciences and the Institute of Pharmaceutical Sciences to launch a new research group for “peptide-based drug discovery” as an Assistant Professor supported by a Starting Grant of the Swiss National Science Foundation.